Thursday, February 23, 2012

Controlled release formulations info free download


Hello readers, controlled release is an efficient form of technique which could useful in drug delivery and biomedical applications along with other applications. Here I would like to describe about brief info regarding controlled release formulations and the link to download of the white paper...Good reading.

Why controlled release required?
The idea of controlled release medication appeared  in order to maintain the gradual release of medication over the period of time.

What are different types of controlled release formulations?
We can classify controlled release formulations in various ways but here I would like to mention the basic classification of formulations.
(1) Slow or sustained controlled release
These formulations control the drug availability by releasing it over an extended period of time.
(2) Triggered release
These formulations are tailored towards drug release in response to environmental stimuli. These formulations allows the selection of medical condition, time and site of delivery.

So what are advantages of Controlled Release Formulations?
(1) As the formulation is given at a constant period of time, dosage efficiency can be achieved by this drug delivery.
(2) Maintenance of constant drug release prevents the drug associated side affects like dose toxicity and ineffective dosage delivery at targeted site. This provides the defined therapeutic benefit of medication.
(3) Providing of constant drug concentration reduces the drug dosage frequency by patient. This improves the patient compliance and medication adherence to the treatment and improves the patient quality of life.
(4) This constant uniform drug release requires less overall active ingredients as the drug availability is more. It is a cost-effective way of formulation.
(5) It also reduces the loss of adjuvants during the manufacturing of formulation.
(6) Controlled release formulations prevents the drug incompatibility as well due it's controlled release of substances.

What factors determines the controlled release technology applications?

  • Physical and chemical property of active ingredient.
  • Route of drug delivery.
  • Market sector and final use of the formulation.

What are different types of controlled release systems:
Reservoir Systems.
Matrix Systems.

Reservoir Systems:

These are based on the confinement of an active agent within a porous or nonporous barrier or shell that protects it temporarily or permanently from the external environment.The core materials of the microcapsules can be solid, liquid or gas. A common method to obtain reservoir-type carriers for controlled release is micro-encapsulation. Encapsulated substances include compounds of varied natures such as drugs, pigments, nutrients, fragrances, anti-microbial compounds, etc.

The main advantage of micro-encapsulation is the separation of the active agent from the medium of storage. This ensures good compatibility and stability of the compounds prior to use, thereby avoiding undesired reactions and facilitating handling which, in turn, increases the lifetime of the product.


Matrix Systems:
The agents are dispersed or dissolved homogeneously throughout a material which is processed into the desired shape and geometry. The geometry of the carrier, the type of material and the concentration of the active agent affect the release rate.





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